反应详情

温度

20 °C

Isoquinoline-6-carboxylic acid (1.2 g, 6.94 mmol) purchased from Gateway Chemical Technology, Inc. was mixed with CDI (1.68 g, 10.4 mmol) in DMF (20 Ml) in a round bottom flask. After the mixture was stirred for 30 minutes at 20° C., anhydrous hydrazine (2 mL) was added and the resulting mixture was stirred at 20° C. for one hour. After removing the solvent at a reduced pressure, the remaining residue was mixed with 20 mL water. After filtration, washing with water and air drying, an off-white solid was obtained as the desired product. LCMS (API-ES) m/z (%): 188.0 (100%, M++H).

1. stirringthe resulting mixture was stirred at 20° C. for one hour
2. customAfter removing the solvent at a reduced pressure
3. additionthe remaining residue was mixed with 20 mL water
4. filtrationAfter filtration
5. washwashing with water and air
6. customdrying