Hydrochloric Acid → HCID 67063119, compound

HRID 599337Notes

Reaction equation

HRID 599337 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([NH:9][CH3:10])[C:6]([N+:11]([O-])=O)=[CH:5][N:4]=1.[ClH:14]>CCO.[Pd]>[ClH:14].[CH3:1][NH:2][C:3]1[N:8]=[C:7]([NH:9][CH3:10])[C:6]([NH2:11])=[CH:5][N:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 255558n,n'-dimethyl-5-nitropyrimidine-2,4-diamine

Product 1

HCID 67063119HCID 67063119, compoundYield 210.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of N2,N4-dimethyl-5-nitropyrimidine-2,4-diamine (4 g, 21.8 mmol) in EtOH was added 10% Pd/C (0.5 g) and 1 N aq HCl solution (10 mL, 10 mmol). The mixture was hydrogenated (30 psi) for 2 h. The reaction mixture was filtered and the filtrate was concentrated to give N2,N4-dimethylpyrimidine-2,4,5-triamine HCl (4 g, 97% yield). 1H NMR (400 MHz, CD3OD): δ 9.00 (s, 1 H), 3.45 (s, 3 H), 3.35 (s, 3 H).

Workup

  1. customfor 2 h
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-9a2f1d19163248539a11c2273d7c6a9a
Source dataset
uspto-grants-2011_03
Patent number
US07897762B2

Reaction notes

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