Hydrochloric Acid → 1-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

HRID 599350Notes

Reaction equation

HRID 599350 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:13][CH:12]3[N:14]([C:15]([N:17]4[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH2:20][CH2:19][CH2:18]4)=[O:16])[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)[CH:2]=1.[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:13][CH:12]3[N:14]([C:15]([N:17]4[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH2:20][CH2:19][CH2:18]4)=[O:16])[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)[CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 249575581-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline

Product 1

HCID 249575571-[(3-Pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

0.146 g of 1-[(3-pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline is dissolved in 6 ml of dichloromethane and 4.2 ml of a 4N solution of hydrochloric acid in dioxane are added. After evaporation, the residue is taken up in ethyl acetate. The precipitate is filtered off and then dried under vacuum. 0.122 g of 1-[(3-pyridin-3-yl-8-azabicyclo[3.2.1]oct-8-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride is obtained.

Workup

  1. customAfter evaporation
  2. filtrationThe precipitate is filtered off
  3. customdried under vacuum

Sources & evidence

ORD record
ord-a8684fedbf374b13a932cb7a737047d2
Source dataset
uspto-grants-2011_03
Patent number
US07897773B2

Reaction notes

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