Hydrochloric Acid → HCID 59848750, compound

HRID 599514Notes

Reaction equation

HRID 599514 reaction equation
[C:1]([C:3]1[C:4]([C:15]2[CH:37]=[CH:36][C:18]([C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[NH:28]C(=O)OC(C)(C)C)=[O:20])=[CH:17][CH:16]=2)=[N:5][CH:6]=[C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH3:14])[CH:8]=1)#[N:2].Cl>O1CCOCC1>[NH2:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:19](=[O:20])[C:18]1[CH:36]=[CH:37][C:15]([C:4]2[C:3]([C:1]#[N:2])=[CH:8][C:7]([CH2:9][O:10][CH2:11][CH2:12][NH:13][CH3:14])=[CH:6][N:5]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59848688HCID 59848688, compound

Product 1

HCID 59848750HCID 59848750, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

t-Butyl (2-{[4-(3-cyano-5-{[2-(methylamino)ethoxy]methyl}pyridin-2-yl)benzoyl]amino}phenyl)carbamate (465 mg, 0.93 mmol, prepared as described in Method 30), 1,4-dioxane (3.5 ml) and a 4M solution of hydrogen chloride in 1,4-dioxane (3.5 ml) were stirred at ambient temperature for 4 hours.

Sources & evidence

ORD record
ord-7e7c7f99e5874971a09a2b0803834123
Source dataset
uspto-grants-2011_03
Patent number
US07897778B2

Reaction notes

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