Hydrochloric Acid → 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valeric acid hydrazide dihydrochloride

HRID 599559Notes

Reaction equation

HRID 599559 reaction equation
[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5]/[C:6](=[CH:18]\[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]2)=[C:21]([O:31][CH3:32])[CH:20]=1)/[C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8]>C(OCC)(=O)C>[ClH:2].[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5]/[C:6](=[CH:18]\[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[C:28]([CH3:30])[N:27]=[CH:26]2)=[C:21]([O:31][CH3:32])[CH:20]=1)/[C:7]([NH:9][NH2:10])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67067180HCID 67067180, compound

Product 1

HCID 670671995-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valeric acid hydrazide dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (1 mL) was added to a solution of tert-butyl N′-{5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}pentanoyl}hydrazinecarboxylate (222 mg) in ethyl acetate (1 mL), and the reaction solution was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure to obtain 208 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-24740a6424424932b2dedb138c9b694c
Source dataset
uspto-grants-2011_03
Patent number
US07897632B2

Reaction notes

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