Hydrochloric Acid → HCID 67067375, compound

HRID 599574Notes

Reaction equation

HRID 599574 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8]>C(OCC)(=O)C>[ClH:2].[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)[C:7]([NH:9][NH2:10])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67067215HCID 67067215, compound

Product 1

HCID 67067375HCID 67067375, compoundYield 162.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 4 N hydrochloric acid in ethyl acetate (2 mL) was added to a solution of tert-butyl N′-[5-chloro-2-(4-fluorophenyl)pentanoyl]hydrazinecarboxylate (517 mg) in ethyl acetate (2 mL), and the reaction solution was stirred at room temperature for four hours. The reaction solution was concentrated under reduced pressure to obtain 342 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8461245426e6441bbbde84ebf511a4f3
Source dataset
uspto-grants-2011_03
Patent number
US07897632B2

Reaction notes

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