Ethyl Acetate → HCID 178489922, compound

HRID 599620Notes

Reaction equation

HRID 599620 reaction equation
C(=O)([O-])[O-].[K+].[K+].C([O:10][CH2:11][CH2:12][CH2:13][CH:14]([C:24]1[NH:28][C:27](/[CH:29]=[CH:30]/[C:31]2[CH:36]=[CH:35][C:34]([N:37]3[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]3)=[C:33]([O:43][CH3:44])[CH:32]=2)=[N:26][N:25]=1)[C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[C:17]([F:23])[CH:16]=1)(=O)C.C(OCC)(=O)C>CO.[Cl-].[Na+].O>[CH3:44][O:43][C:33]1[CH:32]=[C:31](/[CH:30]=[CH:29]/[C:27]2[NH:28][C:24]([CH:14]([C:15]3[CH:16]=[C:17]([F:23])[C:18]([F:22])=[C:19]([F:21])[CH:20]=3)[CH2:13][CH2:12][CH2:11][OH:10])=[N:25][N:26]=2)[CH:36]=[CH:35][C:34]=1[N:37]1[CH:41]=[C:40]([CH3:42])[N:39]=[CH:38]1

Participants

6

Reactant 3

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 178489924HCID 178489924, compound

Product 1

HCID 178489922HCID 178489922, compoundYield 88.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 57417360Sodium chloride; waterSolvent

Procedure

Potassium carbonate (210 mg) was added to a solution of 4-{5-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-4H-[1,2,4]triazol-3-yl}-4-(3,4,5-trifluorophenyl)butyl acetate (400 mg) in methanol (3 mL), and the reaction solution was stirred at room temperature for three hours. Ethyl acetate and brine were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 325 mg of the title compound. The property values of the compound are as follows.

Workup

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-fccde91ebd3a46ecbb8501a5495ca1dd
Source dataset
uspto-grants-2011_03
Patent number
US07897632B2

Reaction notes

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