反应详情

温度

0 °C

A solution of 1-(1-ethyl-propenyl)-4-fluoro-benzene (15.3 g, 93.2 mmol) in THF (150 mL) at −78° C. is treated with n-BuLi (70 mL, 1.6 M). The reaction mixture is allowed to warm to 0° C. over 60 min, cooled to −78° C., and treated with DMF (10.2 g, 140 mmol). The mixture is stirred for 10 min and quenched with HOAc (10 mL) and water (200 mL). The mixture is allowed to warm to RT, and the THF is removed under vacuum. The residue is extracted with EtOAc (2×100 mL, and the organic layer is dried over Na2SO4 and concentrated. The crude product is purified using silica gel column chromatography (7% EtOAc/Hex) to afford the title compound (8.70 g, 49%).

1. temperaturecooled to −78° C.
2. customquenched with HOAc (10 mL) and water (200 mL)
3. temperatureto warm to RT
4. customthe THF is removed under vacuum
5. extractionThe residue is extracted with EtOAc (2×100 mL
6. dry with materialthe organic layer is dried over Na2SO4
7. concentrationconcentrated
8. customThe crude product is purified