Hydrochloric Acid → Ethyl([1,4']bipiperidinyl-4-yloxy)-acetate

HRID 599739Notes

Reaction equation

HRID 599739 reaction equation
[N:1]1([CH:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH2:6][CH2:5][CH:4]([O:7][CH2:8][C:9]([O:11][C:12](C)(C)[CH3:13])=[O:10])[CH2:3][CH2:2]1.Cl>CCO>[CH2:12]([O:11][C:9](=[O:10])[CH2:8][O:7][CH:4]1[CH2:3][CH2:2][N:1]([CH:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[CH2:6][CH2:5]1)[CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86261192Tert-butyl([1,4']bipiperidinyl-4-yloxy)-acetate

Product 1

HCID 57807779Ethyl([1,4']bipiperidinyl-4-yloxy)-acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 100 mg (0.33 mmol) tert.butyl ([1,4′]bipiperidinyl-4-yloxy)-acetate in 1 mL EtOH was combined with 2 mL ethanolic HCl with heating, the mixture was refluxed for a further 2 h and left overnight at RT. The precipitate formed was suction filtered and dried.

Workup

  1. temperaturewith heating
  2. temperaturethe mixture was refluxed for a further 2 h
  3. customThe precipitate formed
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-a8327505435d4236ad192f47c69843fe
Source dataset
uspto-grants-2011_03
Patent number
US07897603B2

Reaction notes

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