Lithium Hydroxide → HCID 135540802, compound

HRID 599758Notes

Reaction equation

HRID 599758 reaction equation
[Li+].[OH-].[O:3]=[C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:39][C:40]3[CH:45]=[C:44]([CH3:46])[C:43]([OH:47])=[C:42]([CH3:48])[CH:41]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][C:34]([O:36]CC)=[O:35])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[N:7]=[C:6]([C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)[NH:5]1>O.C1COCC1>[O:3]=[C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:39][C:40]3[CH:41]=[C:42]([CH3:48])[C:43]([OH:47])=[C:44]([CH3:46])[CH:45]=3)[C:19]([N:21]3[CH2:26][CH2:25][CH:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][C:34]([OH:36])=[O:35])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[N:7]=[C:6]([C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=2)[NH:5]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 135540801HCID 135540801, compound

Product 1

HCID 135540802HCID 135540802, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1.2 mg (0.05 mmol) LiOH in 2 mL water was added to a solution of 21 mg (0.03 mmol) (R)-2-(1′-ethoxycarbonylmethyl-4,4′-bipiperidinyl-1-yl)-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-ethyl 4-(5-oxo-3-phenyl-4,5-dihydro-1,2,4-triazol-1-yl)-piperidine-1-carboxylate in 3 mL THF and the reaction mixture was stirred for 1 h at RT. The THF was evaporated down i.vac., the residue was acidified with 1 M HCl and again evaporated down i.vac. The residue was purified by HPLC, the fractions containing the product were combined and lyophilised.

Workup

  1. customThe THF was evaporated down i.vac
  2. customagain evaporated down i.vac
  3. customThe residue was purified by HPLC
  4. additionthe fractions containing the product

Sources & evidence

ORD record
ord-e69db04254d44743acf675741f2fff6f
Source dataset
uspto-grants-2011_03
Patent number
US07897603B2

Reaction notes

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