Ethyl Acetate → 4-Fluoro-3-nitrobenzyl alcohol

HRID 599842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 599842
[BH4-].[Na+].[F:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][C:5]=1[N+:12]([O-:14])=[O:13].C(OCC)(=O)C>CO.O>[F:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][OH:9])=[CH:6][C:5]=1[N+:12]([O-:14])=[O:13]

Komponenten

6

Edukt 3

HCID 8857Ethyl AcetateHCID 5981294-Fluoro-3-nitrobenzaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 41675874-Fluoro-3-nitrobenzyl alcoholAusbeute 103,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

Sodium borohydride (1.36 g, 35.95 mmol) was added to a solution of 4-fluoro-3-nitrobenzaldehyde (2.0 g, 11.83 mmol) in methanol (15 mL) and water (3.0 mL), and the mixture was stirred at room temperature for 3 hours. Water was then added to the reaction mixture, and extraction was performed with ethyl acetate. The organic extract was washed with saturated saline and dried over magnesium sulfate, and then concentrated under reduced pressure to yield the title compound (2.10 g, 95%) as a pale red oil.

Aufarbeitung

  1. extractionThe organic extract
  2. washwas washed with saturated saline
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e1f1f5224c1e42da9c57b7e740b67605
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897792B2

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