Piperidine → HCID 67272489, compound

HRID 600243Notes

Reaction equation

HRID 600243 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:6][CH2:5]2.[NH:18]1[CH2:22][CH2:21][CH2:20][C@H:19]1[CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.BrC1C=C2C(=CC=1)C[C:35](=[O:40])CC2.N1CCCCC1>>[N:12]1([CH:7]2[CH2:6][CH2:5][C:4]3[CH:3]=[C:2]([C:35]([N:18]4[CH2:22][CH2:21][CH2:20][CH:19]4[CH2:23][N:24]4[CH2:28][CH2:27][CH2:26][CH2:25]4)=[O:40])[CH:11]=[CH:10][C:9]=3[CH2:8]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27335536-Bromo-2-tetraloneHCID 67272710HCID 67272710, compound2×

Product 1

HCID 67272489HCID 67272489, compound

Procedure

(6-Piperidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from 1-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidine and (S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure A. (See herein Example 1). Starting material, (6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-piperidine, was prepared from 6-bromo-2-tetralone and piperidine in a manner substantially analogous to Preparation 1. Mass Spectrum (ES+) 396.

Sources & evidence

ORD record
ord-a693fd8e33ed4e02b02973e51bf255d3
Source dataset
uspto-grants-2011_03
Patent number
US07902191B2

Reaction notes

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