Pyrrolidine → HCID 44216396, compound

HRID 600244Notes

Reaction equation

HRID 600244 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:6][CH2:5]2.[NH:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.BrC1C=C2C(=CC=1)C[C:34](=[O:39])CC2.N1CCCC1>>[N:23]1([CH2:22][CH:18]2[CH2:19][CH2:20][CH2:21][N:17]2[C:34]([C:2]2[CH:11]=[CH:10][C:9]3[CH2:8][CH:7]([N:12]4[CH2:16][CH2:15][CH2:14][CH2:13]4)[CH2:6][CH2:5][C:4]=3[CH:3]=2)=[O:39])[CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

5

Reactant 4

HCID 31268PyrrolidineHCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 27335536-Bromo-2-tetraloneHCID 24753862HCID 24753862, compound2×

Product 1

HCID 44216396HCID 44216396, compound

Procedure

(2-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-(6-pyrrolidin-1-yl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methanone is prepared from 1-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-pyrrolidine and (S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure A. (See herein Example 1). Starting material, (6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-pyrrolidine, was prepared from 6-bromo-2-tetralone and pyrrolidine in a manner substantially analogous to Preparation 1. Mass Spectrum (APCI) 382 (M++1).

Sources & evidence

ORD record
ord-16d3fc266dd7485ca2b35a23a1662cf2
Source dataset
uspto-grants-2011_03
Patent number
US07902191B2

Reaction notes

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