Hydrochloric Acid → (1R,2R)-1-Amino-2-phenylcyclopropane-1-carboxylic acid hydrochloride

HRID 600310Notes

Reaction equation

HRID 600310 reaction equation
[NH2:1][C@:2]1([C:11]([O:13]C)=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:15]>O>[ClH:15].[NH2:1][C@:2]1([C:11]([OH:13])=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14308470methyl (1R,2R)-1-amino-2-phenylcyclopropane-1-carboxylate

Product 1

HCID 12336811(1R,2R)-1-Amino-2-phenylcyclopropane-1-carboxylic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (1R,2R)-methyl 1-amino-2-phenylcyclopropanecarboxylate (14 mg), water (4 mL) and hydrochloric acid (37% w/v, 6 mL) was heated under reflux for 6 h. The mixture was evaporated to dryness, triturated with diethyl ether and the solid collected and dried to give the subtitle compound (14 mg) as a colourless solid.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 h
  3. customThe mixture was evaporated to dryness
  4. customtriturated with diethyl ether
  5. customthe solid collected
  6. customdried

Sources & evidence

ORD record
ord-2697ca3dc3ed4943a0c8c5e28b7f541c
Source dataset
uspto-grants-2011_03
Patent number
US07902181B2

Reaction notes

Loading…