Isobutyl iodide → HCID 59853841, compound

HRID 600609Notes

Reaction equation

HRID 600609 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[N:7]1[CH:15]=[N:14][C:13]2[C:12]3=[N:16][N:17]=[CH:18][N:11]3[C:10](=[O:19])[NH:9][C:8]1=2.C(=O)([O-])[O-].[K+].[K+].[CH2:26](I)[CH:27]([CH3:29])[CH3:28]>CN(C=O)C.O>[CH2:26]([N:9]1[C:8]2[N:7]([CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)[CH:15]=[N:14][C:13]=2[C:12]2=[N:16][N:17]=[CH:18][N:11]2[C:10]1=[O:19])[CH:27]([CH3:29])[CH3:28]

Participants

6

Reactant 3

HCID 10556Isobutyl iodideHCID 11430Potassium CarbonateHCID 135984688HCID 135984688, compound

Product 1

HCID 59853841HCID 59853841, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 7-(tetrahydro-2h-pyran-2-yl)-6,7-dihydro-5h-[1,2,4]triazolo[3,4-i]purin-5-one (2.08 g, 4.0 mmol) in DMF (20 ml), was added potassium carbonate (1.10 g, 8.0 mmol) and isobutyl iodide (1.47 g, 8.0 mmol). The mixture was stirred at room temperature overnight. The reaction was diluted with water and extracted with EtOAc three times. The combined organic layers was dried with sodium sulfate, filtered, and concentrated in vacuo to give the product. LCMS calculated for C15H21N6O2(M+H): 317.2. found: 317.1.

Workup

  1. extractionextracted with EtOAc three times
  2. dry with materialThe combined organic layers was dried with sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customto give the product

Sources & evidence

ORD record
ord-64ce35e37ce749b5838bbd3eec58b3e1
Source dataset
uspto-grants-2011_03
Patent number
US07902205B2

Reaction notes

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