反应详情

Under nitrogen atmosphere, to a solution in which 1,1′-binaphthyl-2,2′-diamine (0.5 mmol) was dissolved in pyridine (1 mL) was added p-toluenesulfonyl chloride (1.1 mmol) at room temperature, and the mixture was reacted for 5 to 12 hours with stirring. After completion of the reaction, the resulting red suspension was diluted with ethyl acetate, and back-extracted with 1N hydrochloric acid to remove pyridine. The resulting organic layer was dried with sodium sulfate to remove the solvent, and the residue was purified by column chromatography to obtain an objective substance as a pale yellow to white solid in more than 95% yield.

1. customthe mixture was reacted for 5 to 12 hours
2. customAfter completion of the reaction
3. extractionback-extracted with 1N hydrochloric acid
4. customto remove pyridine
5. dry with materialThe resulting organic layer was dried with sodium sulfate
6. customto remove the solvent
7. customthe residue was purified by column chromatography
8. customto obtain an objective substance as a pale yellow to white solid in more than 95% yield