反应详情

温度

4 °C

To a solution of 0.324 g of 2-amino-5-trifluoromethylpyridine in 4 mL of DMF cooled to 4° C. is added dropwise a solution of 0.65 g of 3-bromo-1-phenylpropane-1,2-dione in 11 mL of DMF. The reaction mixture is stirred for 16 hours at 4° C. The precipitate is filtered off and washed with diethyl ether, and then dried. 0.32 g of phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrobromide (1:1) is obtained in the form of a white solid.

1. filtrationThe precipitate is filtered off
2. washwashed with diethyl ether
3. customdried