反应详情

Chloro oxime 2e (70 mg; 0.44 mmol), olefin 119 (100 mg; 0.29 mmol) and sodium bicarbonate (50 mg) in ethyl acetate (10 mL) were heated at reflux temperature overnight. The solid was filtered and the filtrate evaporated. The residue was triturated with methanol to yield acid 122.

1. temperatureat reflux temperature overnight
2. filtrationThe solid was filtered
3. customthe filtrate evaporated
4. customThe residue was triturated with methanol