HCID 58976101, compound → HCID 58976675, compound

HRID 601044Notes

Reaction equation

[C:1]([NH:3][C:4](=[N:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:15][CH:14]=1)OC1C=CC=CC=1)#[N:2].[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([C:32]2[N:37]=[C:36]([NH:38][NH2:39])[CH:35]=[CH:34][N:33]=2)[CH2:28][CH2:27]1>CN1CCCC1=O>[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([C:32]2[N:37]=[C:36]([N:38]3[C:1]([NH2:2])=[N:3][C:4]([NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:20][CH2:21][O:22][CH2:23][CH2:24]5)=[CH:17][CH:18]=4)=[N:39]3)[CH:35]=[CH:34][N:33]=2)[CH2:28][CH2:27]1

Participants

Conditions

Temperature: 220 °C

Procedure

A mixture of N-cyano-N′-(4-morpholinopheny)-O-phenylisourea (0.10 g, 0.31 mmol) and [2-(4-Methyl-piperazin-1-yl)-pyrimidin-4-yl]-hydrazine (0.08 g, 0.34 mmol) in N-methylpyrrolidinone (3 mL) was heated in the microwave apparatus at 220° C. for 5 min. Purification by semi-preparative HPLC provided the title compound (0.09 g, 2% yield).

Workup

customPurification by semi-preparative HPLC

Sources & evidence

ORD record: ord-732849bf0e5d4c148c293a02c5035efd
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902239B2

Reaction notes

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