反应详情

Dissolve 2,2-dimethylmorpholine (151 mg, 1.0 mmol) in 1,2-dichloroethane (3 mL) and add glycolaldehyde (60 mg, 1.0 mmol). Stir at room temperature for 30 min followed by addition of NaBH(OAc)3 (233 mg, 1.1 mmol). Stir 3 h, then quench by adding 30 mL of 1N NaOH. Pour into a separatory funnel and extract with EtOAc (2×50 mL). Wash the combined organic layers with brine (50 mL). The crude alcohol was used as is without further purification. MS (ES+) 160.2 (M+1)+.

1. stirringStir 3 h
2. customquench
3. additionby adding 30 mL of 1N NaOH
4. additionPour into a separatory funnel
5. extractionextract with EtOAc (2×50 mL)
6. washWash the combined organic layers with brine (50 mL)
7. customas is without further purification