Triethylamine → HCID 23158109, compound

HRID 601690Notes

Reaction equation

HRID 601690 reaction equation
O[C:2]([CH3:30])([CH3:29])[CH2:3][N:4]1[CH:12](C)[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]3[N:15]=[N:16][N:17]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=4[F:27])[C:18]=3[CH3:19])[CH:10]=2)[C:5]1=[O:28].[CH3:31][S:32](Cl)(=[O:34])=[O:33].C([N:38](CC)CC)C>C(Cl)(Cl)Cl>[CH3:31][S:32]([NH:38][C:2]([CH3:30])([CH3:29])[CH2:3][N:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:14]3[N:15]=[N:16][N:17]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:21]=4[F:27])[C:18]=3[CH3:19])[CH:10]=2)[C:5]1=[O:28])(=[O:34])=[O:33]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 23158278HCID 23158278, compound

Product 1

HCID 23158109HCID 23158109, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

10 mg of the compound obtained in Example 217 was dissolved in 2 ml of chloroform, 20 μl of methanesulfonylchloride and 20 μl of triethylamine were added, and after 30 min at room temperature, the solvents were distilled outunder reduced pressure. The obtained residues were purified by silicagel thin-layer chromatography (ethyl acetate) to obtain 12.3 mg of the above compound as a white solid.

Workup

  1. distillationthe solvents were distilled outunder reduced pressure
  2. customThe obtained residues were purified by silicagel thin-layer chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-db3139a4f58f4e768faf08a201ca4d38
Source dataset
uspto-grants-2011_03
Patent number
US07902369B2

Reaction notes

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