Lithium hydroxide, monohydrate → HCID 44125121, compound

HRID 601805Notes

Reaction equation

HRID 601805 reaction equation
[CH:1]([C:4]1[CH:22]=[CH:21][C:7]([CH2:8][CH:9]2[C:16]3[CH:15]=[C:14]([C:17]([O:19]C)=[O:18])[NH:13][C:12]=3[CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].O.[OH-].[Li+]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]2[C:16]3[CH:15]=[C:14]([C:17]([OH:19])=[O:18])[NH:13][C:12]=3[CH2:11][CH2:10]2)=[CH:21][CH:22]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 59180211HCID 59180211, compound

Product 1

HCID 44125121HCID 44125121, compound

Procedure

The title compound was synthesized from methyl 4-(4-isopropylbenzyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate and lithium hydroxide monohydrate according to General Procedure 7. Silica gel was added, the solvent stripped off and the silica gel-imbedded material was purified by flash chromatography (0-80% EtOAc/Heptane) to give 4-(4-isopropylbenzyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid (33) as a light yellow solid.

Workup

  1. additionSilica gel was added
  2. customthe silica gel-imbedded material was purified by flash chromatography (0-80% EtOAc/Heptane)

Sources & evidence

ORD record
ord-9999901a37e44ae3827d1b9d402f68bd
Source dataset
uspto-grants-2011_03
Patent number
US07902252B2

Reaction notes

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