Lithium Hydroxide → 6-(3,4-Difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

HRID 601922Notes

Reaction equation

HRID 601922 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:13]3[NH:14][C:15]([C:17]([O:19]CC)=[O:18])=[CH:16][C:12]=3[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[Li+]>O>[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:13]3[NH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:12]=3[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 59180205Ethyl 6-(3,4-difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

Product 1

HCID 591800566-(3,4-Difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was synthesized from ethyl 6-(3,4-difluorophenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate and lithium hydroxide in water according to General Procedure 7.

Sources & evidence

ORD record
ord-c365739afb024a83ad1540b257f3bb0b
Source dataset
uspto-grants-2011_03
Patent number
US07902252B2

Reaction notes

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