反应详情

2-Mercapto-4-phenylthiazole (304 mg, 1.54 mmol) and potassium carbonate (261 mg, 1.85 mmol) were added to 1-(tert-butoxycarbonyl)-3-iodomethylpiperidine (500 mg, 1.54 mmol) in N,N-dimethylformamide (5 mL). The mixture was stirred at room temperature for 30 min. Subsequently, water was added and the mixture was extracted with ethyl acetate. The extract was then washed with brine, followed by drying over magnesium sulfate and evaporation of the solvent. Purification of the resulting residue by silica gel column chromatography (hexane:ethyl acetate=40:1->10:1) gave 598 mg (99%) of the desired compound as a colorless oil.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was then washed with brine
3. dry with materialby drying over magnesium sulfate and evaporation of the solvent
4. customPurification of the resulting residue by silica gel column chromatography (hexane:ethyl acetate=40:1->10:1)