反应详情

温度

90 °C

step 3—A solution of 3-bromo-5-methoxy-benzaldehyde (1 mmol) in DMF (2 mL) is added to a round bottomed flask containing Zn(CN)2 (0.7 equivalents), Pd(PPh3)4(0) (0.2 equivalents) in DMF (15 mL). The reaction is stirred at 90° C. under an atmosphere of argon for 48 h. The reaction mixture is cooled and evaporated to dryness. The crude residue is dissolved in EtOAc, washed with brine solution, dried (MgSO4) and evaporated. The crude product is purified by SiO2 chromatography to afford 3-formyl-5-methoxy-benzonitrile.

1. temperatureThe reaction mixture is cooled
2. customevaporated to dryness
3. dissolutionThe crude residue is dissolved in EtOAc
4. washwashed with brine solution
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe crude product is purified by SiO2 chromatography