1-Bromo-3-chloropropane → 4-(3-Chloropropoxy)benzamide

HRID 602628Notes

Reaction equation

HRID 602628 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[Cl:15][CH2:14][CH2:13][CH2:12][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 10796Cesium carbonateHCID 650524-Hydroxybenzamide

Product 1

HCID 144071764-(3-Chloropropoxy)benzamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture composed of 0.004 mole of 4-hydroxybenzamide, 0.004 mole of 1-bromo-3-chloropropane and 0.006 mole of caesium carbonate in 10 ml of acetonitrile is heated at reflux for 5 hours.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 5 hours

Sources & evidence

ORD record
ord-36c142a2e721415a91672a7ac66c67c1
Source dataset
uspto-grants-2011_03
Patent number
US07906547B2

Reaction notes

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