反应详情

温度

40 °C

To a solution of 6-hydroxy-3,4-dihydronaphthalen-1(2H)-one (24.3 g) in acetone (160 mL), benzyl bromide (29.4 mL) and potassium carbonate (31.1 g) were added at room temperature, followed by stirring at 40° C. for 3.5 hours. After filtering off the insoluble matters and concentrating the filtrate, the resultant was washed with a mixed solvent of tert-butyl methyl ether-hexane (1:4), to thereby obtain the title compound (34.5 g) having the following physical properties. TLC: Rf 0.38 (hexane:ethyl acetate=3:1)

1. filtrationAfter filtering off the insoluble matters
2. concentrationconcentrating the filtrate
3. washthe resultant was washed with a mixed solvent of tert-butyl methyl ether-hexane (1:4)