Trifluoroacetic acid → N-(3,4-dichlorophenyl)-4-pyrrolidin-3-ylpiperazine-1-carboxamide

HRID 603204Notes

Reaction equation

HRID 603204 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH:18]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]3)[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:13][CH2:14][N:15]([CH:18]3[CH2:22][CH2:21][NH:20][CH2:19]3)[CH2:16][CH2:17]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57656740Tert-butyl 3-(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)pyrrolidine-1-carboxylate

Product 1

HCID 57656838N-(3,4-dichlorophenyl)-4-pyrrolidin-3-ylpiperazine-1-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 3-(4-{[(3,4-dichlorophenyl)amino]carbonyl}piperazin-1-yl)pyrrolidine-1-carboxylate (690 mg, 1.6 mmol) was dissolved in dichloromethane (50 ml) at room temperature. Trifluoroacetic acid (3 ml) was added and the mixture left to stir for 2 hours then concentrated in vacuo.

Workup

  1. waitthe mixture left
  2. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-91f909c34aee4e5daff34aa17a9f94b8
Source dataset
uspto-grants-2011_03
Patent number
US07906645B2

Reaction notes

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