Acetyl chloride → HCID 756919, compound

HRID 603262Notes

Reaction equation

HRID 603262 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>O1CCCC1>[C:21]([N:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1)(=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 759941-Benzylpiperazine

Product 1

HCID 756919HCID 756919, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-benzylpiperazine (1 g) and triethylamine (1.19 mL) in tetrahydrofuran (20 mL) was stirred at room temperature under argon. Acetyl chloride (0.424 mL) was added and the mixture was stirred for 10 minutes. The reaction was filtered and the white solid washed with ether. The filtrate was concentrated at reduced pressure to give the title compound as a colourless oil (1.2 g).

Workup

  1. filtrationThe reaction was filtered
  2. washthe white solid washed with ether
  3. concentrationThe filtrate was concentrated at reduced pressure

Sources & evidence

ORD record
ord-d4cc9d3b5e924df2b3de7c39496daac3
Source dataset
uspto-grants-2011_03
Patent number
US07906645B2

Reaction notes

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