2,4-Dichloro-5-fluoropyrimidine → N2,N4-bis(indol-6-yl)-5-fluoro-2,4-pyrimidinediamine

反応式

Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][CH:12]=1>>[NH:17]1[C:18]2[C:14](=[CH:13][CH:12]=[C:11]([NH:10][C:2]3[N:7]=[C:6]([NH:10][C:11]4[CH:19]=[C:18]5[C:14]([CH:15]=[CH:16][NH:17]5)=[CH:13][CH:12]=4)[C:5]([F:9])=[CH:4][N:3]=3)[CH:19]=2)[CH:15]=[CH:16]1

参加物

反応物 2

HCID 2507052,4-Dichloro-5-fluoropyrimidine

HCID 2560966-Aminoindole

生成物 1

HCID 11552202N2,N4-bis(indol-6-yl)-5-fluoro-2,4-pyrimidinediamine

実験手順

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to yield N2,N4-bis(indol-6-yl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 22.39 min.; purity: 85%; MS (m/e): 359 (MH+).

後処理

customwere reacted

出典と根拠

ORDレコード: ord-a96749cdaad9426bb4b7f79f5dcc3631
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07906644B2

反応ノート

読み込み中…