反应详情

温度

120 °C

2-Fluoro-5-trifluoromethyl-benzaldehyde (2.7 g) and ethyl-(2-methoxy-ethyl)-amine (2.18 g) are dissolved in toluene (20 ml), and thereto is added potassium carbonate (5.83 g) and the mixture is stirred at 120° C. overnight. The reaction solution is cooled to room temperature, and thereto are added ethyl acetate and a saturated brine and the mixture is separated, and the organic layer is washed with a saturated brine, and the mixture is dried over magnesium sulfate and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (hexane:ethyl acetate=19:1→4:1) to give 2-[ethyl-(2-methoxy-ethyl)-amino]-5-trifluoromethyl-benzaldehyde (3.75 g). MS (m/z): 276 [M+H]+

1. temperatureThe reaction solution is cooled to room temperature
2. customa saturated brine and the mixture is separated
3. washthe organic layer is washed with a saturated brine
4. dry with materialthe mixture is dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue is purified by silica gel column chromatography (hexane:ethyl acetate=19:1→4:1)