1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 59650735, compound

HRID 604327Notes

Reaction equation

HRID 604327 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([N:12]([CH2:14][C:15]([OH:17])=[O:16])[CH3:13])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:18]([C@:20]1(O)[C:48]2[CH:47]=[C:46]3[N:26]([CH2:27][C:28]4[C:29]3=[N:30][C:31]3[C:32]5[C:33]=4[N:34]([CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH:35]=[N:36][C:37]=5[CH:38]=[CH:39][CH:40]=3)[C:25](=[O:49])[C:24]=2[CH2:23][O:22][C:21]1=[O:50])[CH3:19].Cl.C(N=C=NCCCN(C)C)C>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([N:12]([CH2:14][C:15]([O:17][C@@:20]1([CH2:18][CH3:19])[C:48]2[CH:47]=[C:46]3[N:26]([CH2:27][C:28]4[C:29]3=[N:30][C:31]3[C:32]5[C:33]=4[N:34]([CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH:35]=[N:36][C:37]=5[CH:38]=[CH:39][CH:40]=3)[C:25](=[O:49])[C:24]=2[CH2:23][O:22][C:21]1=[O:50])=[O:16])[CH3:13])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 9981577HCID 9981577, compoundHCID 10977741Glycine, N-[(1,1-dimethylethoxy)carbonyl]glycyl-N-methyl-

Product 1

HCID 59650735HCID 59650735, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

1.4 g (5.67 mmol) of [N-(tert-butoxycarbonyl)-glycyl]-sarcosine, which is a known substance (Helvetica Chimica Acta, 1991, 74, 197), 1.3 g (2.84 mmol) of (9S)-9-ethyl-9-hydroxy-1-pentyl-1H,12H-pyrano[3″,4″:6′,7′]indolizino[1′,2′:6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione, 2.2 g (11.34 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, and 1.4 g (11.34 mmol) of 4-dimethylaminopyridine were dissolved in methylene chloride (50 mL), and then stirred at room temperature for 1.5 hours.

Sources & evidence

ORD record
ord-acbb5c36508f437d990402af55a6a518
Source dataset
uspto-grants-2011_03
Patent number
US07910593B2

Reaction notes

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