反应详情

2-Amino-4-phenyl-thiazole-5-carbonitrile (0.13 g, 0.6 mmol) was suspended in 1:1 water/ethanol (v/v) (24 mL) and added hydroxylamine hydrochloride (1.47 g, 21 mmol) and potassium carbonate (1.86 g, 13 mmol). The reaction mixture was heated at reflux for 3 days, then the solvent was reduced and the aqueous phase was extracted with dichloromethane. The organic layer was washed with water and brine, and was dried over sodium sulfate. The solvent was evaporated to yield a yellow solid. Yield: 0.1 g, 66%.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 3 days
3. extractionthe aqueous phase was extracted with dichloromethane
4. washThe organic layer was washed with water and brine
5. dry with materialwas dried over sodium sulfate
6. customThe solvent was evaporated
7. customto yield a yellow solid