Cyclopropanecarbonyl chloride → Cyclopr-opanecarboxylic acid (5-furan-3-yl-4-phenyl-thiazol-2-yl)-amide

HRID 604494Notes

Reaction equation

HRID 604494 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([NH2:11])=[N:8][C:7]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:2]1.[CH:18]1([C:21](Cl)=[O:22])[CH2:20][CH2:19]1>N1C=CC=CC=1>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([NH:11][C:21]([CH:18]3[CH2:20][CH2:19]3)=[O:22])=[N:8][C:7]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:2]1

Participants

4

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 577096105-Furan-3-yl-4-phenyl-thiazol-2-ylamine

Product 1

HCID 11493318Cyclopr-opanecarboxylic acid (5-furan-3-yl-4-phenyl-thiazol-2-yl)-amide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

100 μL of a 0.3M stock solution of 5-furan-3-yl-4-phenyl-thiazol-2-ylamine and 120 μL of a 0.3M stock solution of pyridine were mixed with 120 μL of a 0.3M stock solution of cyclopropanecarbonyl chloride. The reaction mixture was shaken overnight at ambient temperature. Purification was performed by preparative LC-MS.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-f674dbf0c5a04b2a85c121fbb8414df3
Source dataset
uspto-grants-2011_03
Patent number
US07910613B2

Reaction notes

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