反应详情

Methyl iodide (7.7 mL, 124 mmol) was added to a solution of 2-(N,N-dimethylaminomethyl)-1-ethylpyrrol (15.6 g, 102 mmol) in ethanol (150 mL) under ice-cooling and the mixture was stirred at room temperature for 3 hours. Ethyl acetate (150 mL) was added to the reaction mixture and the precipitated crystal was collected by filtration. After the crystal was washed with ethyl acetate and dried to obtain (1-ethylpyrrol-2-yl)methyltrimethylammonium iodide (20.0 g, yield: 66%).

1. temperaturecooling
2. filtrationthe precipitated crystal was collected by filtration
3. washAfter the crystal was washed with ethyl acetate
4. customdried