Urea → HCID 178517731, compound

HRID 604849Notes

Reaction equation

HRID 604849 reaction equation
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[C:9]([P:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:11][CH:12]=1)=O.[NH2:27][C:28]([NH2:30])=[O:29]>C(O)C>[OH:29][C:28]1[N:30]=[C:5]([C:7]2[CH:8]=[C:9]([P:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:10]=[CH:11][CH:12]=2)[CH:4]=[CH:3][N:27]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 72566760HCID 72566760, compound

Product 1

HCID 178517731HCID 178517731, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 mmol of 4 are dissolved in 100 ml of aqueous ethanol and mixed with 25 mmol of urea. It is refluxed for 7 h, the solvent is removed and the colorless solid is washed with water. Recrystallization from chloroform gives 20 in a yield above 90%. ESI MS, m/z (%): 366.3703 (100) [M+H]+. 31P{1H} NMR (101.2 MHz, 25° C., DMSO-d6): 5-7.45.

Workup

  1. temperatureIt is refluxed for 7 h
  2. customthe solvent is removed
  3. washthe colorless solid is washed with water
  4. customRecrystallization from chloroform

Sources & evidence

ORD record
ord-0cdf43de5a614aeb843cb1f20bcbf34b
Source dataset
uspto-grants-2011_03
Patent number
US07910744B2

Reaction notes

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