2-Fluoroaniline → HCID 67040494, compound

HRID 605097Notes

Reaction equation

HRID 605097 reaction equation
[CH2:1]([O:8][C:9]1[CH:38]=[CH:37][C:12]([O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][C:15]=2[NH:23][C:24]2[C:25]3[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[N:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)C(C)C)(C)C.[F:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][C:50]=1[NH2:55]>ClCCl>[CH2:1]([O:8][C:9]1[CH:38]=[CH:37][C:12]([O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH:55][C:50]3[CH:51]=[CH:52][CH:53]=[CH:54][C:49]=3[F:48])=[O:19])=[CH:16][C:15]=2[NH:23][C:24]2[C:25]3[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[N:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 95842-FluoroanilineHCID 81531DiisopropylethylamineHCID 86615545HCID 86615545, compound

Product 1

HCID 67040494HCID 67040494, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product from Example 43D (53 mg, 0.1 mmol), N,N-diisopropylethylamine (0.052 mL, 0.3 mmol), 2-Fluoro-phenylamine (0.014 mL, 0.15 mmol) in dichloromethane (2 mL) was stirred at room temperature for 1 hour, then concentrated under vacuum to provide the title product.

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-c6656169a4764329a84642a733dc1654
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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