Water → HCID 2088519, compound

HRID 605157Notes

Reaction equation

HRID 605157 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F:12][C:13]([F:24])([F:23])[C:14]1[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=1)[C:17](Cl)=[O:18].CCN(C(C)C)C(C)C.O>O1CCCC1>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:17](=[O:18])[C:16]2[CH:20]=[CH:21][CH:22]=[C:14]([C:13]([F:12])([F:23])[F:24])[CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

6

Reactant 4

HCID 962WaterHCID 677684-Fluoro-3-nitroanilineHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 81531Diisopropylethylamine

Product 1

HCID 2088519HCID 2088519, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-Fluoro-3-nitro-aniline (2.00 g, 12.8 mmol), 3-Trifluoromethyl-benzoyl chloride (1.895 mL, 12.8 mmol), Hunig's base (4.463 mL, 25.6 mmol) in tetrahydrofuran (50 ml) was stirred at room temperature for 1 hour. Afterwards water (450 mL) was added to the solution and the resultant solid was collected by filtration and dried in a vacuum oven to provide the title compound (3.311 g, 97%).

Workup

  1. filtrationthe resultant solid was collected by filtration
  2. customdried in a vacuum oven

Sources & evidence

ORD record
ord-3bb70ae2f006465bbe1792d2d42b2720
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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