Potassium Carbonate → HCID 67041095, compound

HRID 605256Notes

Reaction equation

HRID 605256 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[S:12][C:13]([Br:16])=[CH:14][CH:15]=2)=[O:10])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C([O-])([O-])=O.[K+].[K+].[SH:26][C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1>CN(C=O)C.O>[OH:33][C:30]1[CH:31]=[CH:32][C:27]([S:26][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]3[S:12][C:13]([Br:16])=[CH:14][CH:15]=3)=[O:10])=[CH:4][C:3]=2[N+:17]([O-:19])=[O:18])=[CH:28][CH:29]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 2401474-MercaptophenolHCID 2649530HCID 2649530, compound

Product 1

HCID 67041095HCID 67041095, compoundYield 78.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The product of Example 241b (1.50 g, 4.34 mmol) was dissolved in DMF to which K2CO3 (1.20 g, 8.69 mmol), and 4-mercapto-phenol (548 mg, 4.34 mmol) were added. The reaction mixture was then heated to 80° C. for 2 hrs. At this point the reaction mixture was cooled to room temperature and diluted with water which was then extracted with ethyl acetate to isolate the desired compound (1.54 g, 78%).

Workup

  1. additionwere added
  2. temperatureAt this point the reaction mixture was cooled to room temperature
  3. extractionwas then extracted with ethyl acetate

Sources & evidence

ORD record
ord-e561d62a4b0148c687794318bd4ec710
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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