Potassium Carbonate → HCID 67040858, compound

HRID 605258Notes

Reaction equation

HRID 605258 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[CH:4][C:3]=1[N+:21]([O-:23])=[O:22].C([O-])([O-])=O.[K+].[K+].[C:30]([C:34]1[CH:39]=[CH:38][C:37]([SH:40])=[CH:36][CH:35]=1)([CH3:33])([CH3:32])[CH3:31]>CN(C=O)C.O>[C:30]([C:34]1[CH:35]=[CH:36][C:37]([S:40][C:2]2[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=3)=[CH:4][C:3]=2[N+:21]([O-:23])=[O:22])=[CH:38][CH:39]=1)([CH3:33])([CH3:31])[CH3:32]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 754544-Tert-ButylbenzenethiolHCID 2088519HCID 2088519, compound

Product 1

HCID 67040858HCID 67040858, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The product from Example 242a (600 mg, 1.828 mmol) was dissolved in DMF (20 ml) to which K2CO3 (505 mg, 3.656 mmol), and 4-tert-Butyl-benzenethiol (304 mg, 1.828 mmol) were added. This reaction mixture was then heated to 80° C. for 1 hr. At this time the reaction mixture was cooled to room temperature, diluted with water, and the title compound collected by filtration (311 mg, 35%)

Workup

  1. additionwere added
  2. temperatureAt this time the reaction mixture was cooled to room temperature
  3. filtrationthe title compound collected by filtration (311 mg, 35%)

Sources & evidence

ORD record
ord-986a7b19d5254a399f1f0f5f07225ff0
Source dataset
uspto-grants-2011_03
Patent number
US07910595B2

Reaction notes

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