反应详情

4-Nitrophenyl chloroformate (7.0 g) was added to a dichloromethane (100 ml) solution of methyl 5-hydroxynicotinate (5.3 g) and diisopropylethylamine (6.1 ml), followed by stirring at room temperature for 1 hour. The reaction liquid was washed with water, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the resulting solid was washed with EtOAc/hexane and dried under reduced pressure to obtain methyl 5-{[(4-nitrophenoxy)carbonyl]oxy}nicotinate (8.4 g).

1. customThe reaction liquid
2. washwas washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated
5. washthe resulting solid was washed with EtOAc/hexane
6. customdried under reduced pressure