Acetonitrile → HCID 8607861, compound

HRID 605812Notes

Reaction equation

HRID 605812 reaction equation
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].C(#N)C.[OH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH2:24])=[O:23])=[CH:20][CH:19]=1>O>[NH2:24][C:22]([C:21]1[CH:25]=[CH:26][C:18]([O:17][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:19][CH:20]=1)=[O:23]

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 650524-Hydroxybenzamide

Product 1

HCID 8607861HCID 8607861, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

Potassium carbonate (1.04 g) and ethyl bromoacetate (0.610 ml) were added to an acetonitrile (15 ml) solution containing 4-hydroxybenzamide (686 mg), followed by heating at 80° C. for 2 hours. The reaction solution was cooled, water (45 ml) was added thereto, and the precipitated solid was collected by filtration, washed with water and dried to obtain ethyl [4-(aminocarbonyl)phenoxy]acetate (893 mg) as pale brown powder.

Workup

  1. temperatureThe reaction solution was cooled
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-bdd48566b794406aba505df434502d03
Source dataset
uspto-grants-2011_03
Patent number
US07915261B2

Reaction notes

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