反应详情

To a solution of (2-fluoro-6-iodophenyl)methanol (10 mmol) in 50 mL of THF was added NaH (12 mmol) in small portions at room temperature. After the addition, allylbromide (12 mmol) was added slowly via syringe. The reaction mixture was stirred 16 hours at room temperature. The resulting white heterogeneous mixture was quenched with water and then diluted with 100 mL of Et2O, followed by washing with water and brine. The organic layer was dried over MgSO4 and then concentrated to dryness in vacuo to offer 2.8 g of the title compound.

1. additionwas added slowly via syringe
2. customThe resulting white heterogeneous mixture was quenched with water
3. additiondiluted with 100 mL of Et2O
4. washby washing with water and brine
5. dry with materialThe organic layer was dried over MgSO4
6. concentrationconcentrated to dryness in vacuo