Hydrazine hydrate (1:1) → (5-phenylisoxazol-3-yl)methylamine

HRID 606136Notes

Reaction equation

HRID 606136 reaction equation
[C:1]1([C:7]2[O:11][N:10]=[C:9]([CH2:12][N:13]3C(=O)C4C(=CC=CC=4)C3=O)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>>[C:1]1([C:7]2[O:11][N:10]=[C:9]([CH2:12][NH2:13])[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 17473432HCID 17473432, compound

Product 1

HCID 5200315(5-phenylisoxazol-3-yl)methylamine

Procedure

2-[(5-Phenylisoxazol-3-yl)methyl]-1H-isoindole-1,3(2H)-dione (3.48 g, 11.4 mmol) was treated with hydrazine hydrate (1.35 g, 22.9 mmol) according to the method described in Part E of Example 35 to provide (5-phenylisoxazol-3-yl)methylamine as a pale yellow solid.

Sources & evidence

ORD record
ord-c6b2f48cd79a40bcac189b9549856a77
Source dataset
uspto-grants-2011_03
Patent number
US07915281B2

Reaction notes

Loading…