反应详情

After dissolving 221 mg of 2-tert-butoxy-4-vinylpyrimidine and 200 mg of 4-(2-fluorophenoxymethyl)piperidine hydrochloride in 5 ml of ethanol, 123 mg of anhydrous potassium carbonate was added and the mixture was heated to reflux for 50 minutes. Ethyl acetate was added to the reaction mixture, the insoluble portion was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain the title compound (293 mg, 93% yield).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 50 minutes
4. filtrationthe insoluble portion was filtered off
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate)