Benzyl Bromide → Piperidinium, 1-methyl-4-oxo-1-(phenylmethyl)-, bromide

HRID 606324Notes

Reaction equation

HRID 606324 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[Br:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CC(C)=O>[Br-:9].[CH2:10]([N+:2]1([CH3:1])[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 740491-Methyl-4-piperidone

Product 1

HCID 10802960Piperidinium, 1-methyl-4-oxo-1-(phenylmethyl)-, bromide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 1-methyl-4-piperidinone (15 g, 132.6 mmol) in dry acetone (100 mL) was added 1-bromomethylbenzene (24.9 g, 145 mmol) dropwise. It was stirred for 3 h. The title compound (116) separated which was filtered, washed with dry acetone and dried.

Workup

  1. customThe title compound (116) separated which
  2. filtrationwas filtered
  3. washwashed with dry acetone
  4. customdried

Sources & evidence

ORD record
ord-27e1b8da45184bc6857d2f5550f04015
Source dataset
uspto-grants-2011_03
Patent number
US07915301B2

Reaction notes

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