反应详情

A solution of 5-methyl-4-oxo-N-({2-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}ethyl)oxy]pyridin-4-yl}methyl)-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide (395.0 mg, 0.576 mmol), triethylsilane (0.097 mL, 0.605 mmol) and trifluoroacetic acid (3.0 mL) in dichloromethane (10 mL) was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate-IPE to give the title compound as a white powder (53.6 mg, 21%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was crystallized from ethyl acetate-IPE