反应详情

A solution of 6-cyano-4-oxo-N-{[3-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoyl}amino)phenyl]methyl}-3,4-dihydroquinazoline-2-carboxamide (215 mg, 0.314 mmol), triethylsilane (0.053 mL, 0.330 mmol) and trifluoroacetic acid (2 mL) in dichloromethane (3 mL) was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from IPE. The resulting powder was recrystallized from ethanol to give is the title compound as a white powder (98.6 mg, 71%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was crystallized from IPE
3. customThe resulting powder was recrystallized from ethanol
4. customto give