反应详情

To a suspension of ethyl ((2-(aminocarbonyl)-4-iodophenyl)amino)(oxo)acetate (20.9 g, 57.7 mmol) in ethanol (300 mL) was added dropwise sodium ethylate (20% ethanol solution, 21.6 g, 63.5 mmol) under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into 0.3N hydrochloric acid (600 mL) under ice-cooling, and the precipitated insoluble material was collected by filtration. The filtered cake was washed with water and ethanol to give ethyl 6-iodo-4-oxo-3,4-dihydroquinazoline-2-carboxylate as a pale-pink powder (17.0 g, 86%).

1. temperaturecooling
2. temperaturecooling
3. filtrationthe precipitated insoluble material was collected by filtration
4. washThe filtered cake was washed with water and ethanol