Lithium Hydroxide → 3-Methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylic acid

HRID 606585Notes

Reaction equation

HRID 606585 reaction equation
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([O:11][CH2:12][CH:13]3[O:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:20]([O:22]CC)=[O:21].[OH-].[Li+]>O1CCCC1>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([O:11][CH2:12][CH:13]3[O:18][CH2:17][CH2:16][N:15]([CH3:19])[CH2:14]3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:20]([OH:22])=[O:21]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67046419Ethyl 3-methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylate

Product 1

HCID 582568383-Methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 3-methyl-5-(4-methyl-morpholin-2-ylmethoxy)-benzofuran-2-carboxylate (0.12 mmol) was dissolved in 300 μl of tetrahydrofuran. Then 300 μl of a 1.0 M solution of lithium hydroxide were added and the mixture stirred at room temperature for 3 hours. The tetrahydrofuran was removed under vacuo and the water eliminated by lyophilisation to yield the tilted compound as a white solid: m/z=304 in MS ES−.

Workup

  1. customThe tetrahydrofuran was removed under vacuo

Sources & evidence

ORD record
ord-647f61e6862b4defa7db33b1339d8deb
Source dataset
uspto-grants-2011_03
Patent number
US07915300B2

Reaction notes

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